During the Thieves Guild questline in Andothren where you meet Three Eyes for the first time, instead of interacting and talking with Three Eyes, either a blank dialogue screen appears or it swaps to a frozen dialogue screen for Angunas. On exiting the dialogue, everything bar the inventory screen is frozen (cannot move and cannot look around). On further inspection, even getting near him seems to freeze the game. Shooting him with a with a projectile breaks the game's physics, meaning that my chracater, the NPCs and projectiles are frozen in place (but the game is not actually frozen), and this one attack also boosts my marksman skill all the way from 60 to 100. I put it down as major bug as it's part of a faction quest, and no progression in the storyline can be made due to this.